Old name, new purpose: why we’ve gone back to RNID

2023 Hearing Therapeutics Summit

Talk: Dr Gaëlle Naert

Hearing in background noise: the path toward future treatments using digital evaluation

Dr Gaëlle Naert, CILCARE

Alterations in our sensory senses are gaining more and more interest as potential biomarkers. Hearing impairment is a comorbidity of multiple neuro-inflammatory diseases which may precede their onset. Insidious and highly prevalent, cochlear synaptopathy is a form of hearing disorder which refers to the difficulty of understanding in noisy environment, and is still difficult to assess in the clinic, lacking standard diagnostic methods, computational tools, and sensitive auditory tests.

Tremendous progress has been done in translational research over the few past years, providing evidence of underlying neurophysiological pathologies involved in cochlear synaptopathy, that will lead to emerging therapeutic intervention. This presentation provides a landscape review of preclinical and clinical research focused on cochlear synaptopathy. It aims at describing how digital auditory signatures could be an essential building block in the early definition, detection, and treatment of cochlear synaptopathy, as well as their potential application for deafness and associated diseases prevention.

About Dr Gaëlle Naert

Chief Scientific and Operations Officer, CILCARE, France

Dr. Gaëlle Naert joined CILcare in 2016 and has over 15 years of experience in life sciences, including preclinical development, operations management, and compliance. She is currently responsible for leading preclinical organization at CILcare France and plays a key role in the development of CILcare’s pipeline, especially in the translation between the preclinical and clinical stages.

Prior to CILcare, Dr. Naert worked on the development of animal models to investigate the therapeutic avenues of major Central Nervous System disorders, such as depression and Alzheimer’s disease, neuro-inflammation processes which relate to otic and hearing diseases.

Expert in neurotology, she has also a wide range of project management and business development competencies, and is the author of many scientific communications and publications, as well as receiving many scholarships and awards. Dr. Naert holds a Ph.D in Cellular and Molecular Endocrinology from the University of Montpellier, France, a Post-doc in Neuroimmunology from the Research Centre of Laval University, Canada, and in Kinases in Alzheimer’s disease from the University of Montpellier, France.

Satellite event of the 58th Inner Ear Biology Meeting